Some nodes are time based, like the Clock node, Delay node, Stopwatch node and even the Camera node. When these nodes are added to a flow, a playback button will appear. This allows you to pause and play all the nodes with a time component.
Playing
Paused
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Keyboard shortcuts: Play: Command + I, Pause: Command + O.
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Time based nodes can be heavy, so keep out for the memory warning. If you get a memory warning, time will automatically pause to avoid a crash.